What does it mean to become negative for hepatitis B virus?
Recently, the topic of becoming negative for hepatitis B virus has sparked widespread discussion on social media and health forums. Many patients have questions about the meaning, clinical significance and implementation of "turning negative". This article will combine the hot content of the past 10 days and present relevant information with structured data to help readers fully understand this concept.
1. Definition of hepatitis B virus negative conversion
Hepatitis B virus conversion usually means that one of the following two results is found through testing:
| Detection indicators | Negative conversion standard | clinical significance |
|---|---|---|
| Hepatitis B surface antigen (HBsAg) | Not detected in blood | Virus replication stopped or extremely low |
| HBV-DNA | Below the detection limit | Significant reduction in viral load |
2. Common ways to achieve negative conversion
According to the popular science data of medical accounts in the past 10 days, the main ways to turn negative include:
| Way | Proportion | Applicable people |
|---|---|---|
| Naturally turning negative | 5%-10% | Patients with strong immune systems |
| drug treatment | 60%-70% | Chronic hepatitis B patients |
| combination therapy | 20%-30% | Drug-resistant or refractory patients |
3. Recent hot topics of discussion
1.Progress of new drugs: The 5-year follow-up data of TAF (tenofovir alafenamide) shows that the negative conversion rate is 12% higher than that of traditional drugs.
2.Cure Standards Controversy: Some experts believe that it is necessary to achieve both HBsAg and HBV-DNA negative conversion before it can be considered clinically cured.
3.False propaganda warning: Health commissions in many places have issued announcements to remind patients to be wary of illegal medical advertisements that "guaranteed to turn negative in three months."
4. Key data that patients need to know
| index | Recommendations after turning negative | Relapse probability |
|---|---|---|
| Only HBV-DNA turns negative | Continue taking the medication for 6-12 months | 15%-25% |
| HBsAg turns negative | Review once a year | 3%-8% |
| Antibodies appear | Treatment can be stopped | <1% |
5. Latest suggestions from experts (updated in 2023)
1. Liver function still needs to be monitored for at least 3 years after turning negative
2. Avoid high-risk behaviors such as drinking alcohol and staying up late
3. Hepatitis B vaccination can reduce the risk of reinfection
Conclusion: Conversion of hepatitis B virus to negative is a staged treatment result, but it needs to be judged comprehensively based on multiple indicators. Recent studies have found that even if conversion is achieved, the progression of liver fibrosis still requires attention. It is recommended that patients undergo regular follow-up visits through regular medical institutions to avoid blindly pursuing negative results and neglecting overall health management.
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